(S)-GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase alpha (PI4KIIIalpha). (S)-GSK-F1 inhibits PI4Kalpha, PI4Kbeta, PI4Kgamma, PI3Kalpha, PI3Kbeta and PI3Kdelta with pIC50 of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S)-GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S)-GSK-F1 exhibits moderate pharmacokinetic characters in rat model[1].
Molekulargewicht:
603.52
CAS Nummer:
[1384097-27-1]
Formel:
C27H18F5N5O4S
Target-Kategorie:
PI3K,PI4K
Anwendungsbeschreibung:
Reference compound
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