Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. target: phosphodiesterase (PDE)[3], IC 50: 0.036 microM, [3] In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [4]
Molekulargewicht:
459.55
Reinheit:
99.75
CAS Nummer:
[133718-29-3]
Formel:
C26H29N5O3
Target-Kategorie:
Phosphodiesterase (PDE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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