AZ0108 is an inhibitor for poly ADP-ribose polymerase (PARP), which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC50s of 3 µM, respectively. AZ0108 prevents centrosome clustering with an EC50 of 0.053 µM, and exhibits cytotoxicity in cell OCI-LY-19 with GI50 of 0.017 µM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models[1].
Molekulargewicht:
500.45
CAS Nummer:
[1825345-52-5]
Formel:
C24H20F4N6O2
Target-Kategorie:
PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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