TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4].
Molekulargewicht:
380.85
Reinheit:
99.91
CAS Nummer:
[1952251-28-3]
Formel:
C17H22ClFN6O
Target-Kategorie:
FLT3,Syk
Anwendungsbeschreibung:
MCE Product type: Reference compound
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