(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 µM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 µM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
Molekulargewicht:
102.09
Reinheit:
99.83
CAS Nummer:
[24587-49-3]
Formel:
C4H6O3
Target-Kategorie:
GABA Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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