MBM-55S is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55S shows antitumor activities, and no obvious toxicity to mice[1].
Molekulargewicht:
734.73
CAS Nummer:
[2083624-07-9]
Formel:
C36H39FN6O10
Target-Kategorie:
Apoptosis,DYRK,NEKs,Ribosomal S6 Kinase (RSK)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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