TAN-67 (SB-205607) is a non-peptidic delta-opioid receptor agonist that exhibits significant antinociceptive activity in both diabetic and non-diabetic mice. TAN-67 demonstrates a marked and dose-dependent reduction in acetic acid-induced abdominal constrictions, with a notably stronger effect in diabetic mice compared to their non-diabetic counterparts. TAN-67s antinociceptive properties are primarily mediated through the activation of delta 1-opioid receptors, as indicated by the pronounced antagonism observed upon administration of a selective delta 1-opioid receptor antagonist.
Molekulargewicht:
344.45
CAS Nummer:
[148545-09-9]
Formel:
C23H24N2O
Target-Kategorie:
Opioid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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