L748337 is a potent beta3-adrenergic receptor antagonist and displays selectivity over beta1 and beta2 receptors. The Ki values of L748337 for beta3-, beta2- and beta1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively[1]. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6[2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases[1][2][3].
Molekulargewicht:
497.61
Reinheit:
99
CAS Nummer:
[244192-94-7]
Formel:
C26H31N3O5S
Target-Kategorie:
Adrenergic Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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