Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1alpha-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1alpha auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM[1][2][3].
Molekulargewicht:
291.26
Reinheit:
99.40
CAS Nummer:
[606-58-6]
Formel:
C12H13N5O4
Target-Kategorie:
Antibiotic,Apoptosis,CDK,Fungal,IRE1
Anwendungsbeschreibung:
MCE Product type: Natural Products
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