Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210bcr/abl inhibitor (IC50=14 µM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells[1][2][3].
Molekulargewicht:
393.48
Reinheit:
99.02
CAS Nummer:
[241127-58-2]
Formel:
C24H27NO4
Target-Kategorie:
Apoptosis,Bcr-Abl
Anwendungsbeschreibung:
MCE Product type: Reference compound
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