DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC50s: 0.14, 0.95, 50.72 µM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 µM. DCPIB is a useful tool for investigating structure-function studies of K2P channels[1][2].
Molekulargewicht:
427.36
Reinheit:
99.83
CAS Nummer:
[82749-70-0]
Formel:
C22H28Cl2O4
Target-Kategorie:
Chloride Channel,Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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