Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride hydrate inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 µM. Samuraciclib hydrochloride hydrate has anti-tumor effects[1][2].
Molekulargewicht:
521.70
Reinheit:
99.90
Formel:
C22H30N6O.(2.5HCl).(2H2O)
Target-Kategorie:
Apoptosis,CDK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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