Talmapimod (hydrochloride ), CAS [[2387505-88-4]] Preis auf Anfrage
Artikelnummer:
MCE-HY-10406A
Hersteller Artikelnummer:
HY-10406A
Alternativnummer:
MCE-HY-10406A-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
SCIO-469 (hydrochloride )
Talmapimod (SCIO-469) hydrochloride is an orally active and selective inhibitor of p38alpha MAPK with an IC50 of 9 nM. Talmapimod hydrochloride inhibits the secretion of inflammatory factors (such as TNFalpha, IL-1beta, IL-6, and VEGF) by suppressing the p38alpha MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod hydrochloride inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod hydrochloride can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome)[1][2][3][4].
