iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats[1].
Molekulargewicht:
400.48
CAS Nummer:
[1214914-38-1]
Formel:
C21H31F3N2O2
Target-Kategorie:
Dopamine Transporter,Serotonin Transporter
Anwendungsbeschreibung:
MCE Product type: Reference compound
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