SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-beta receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 µM, 0.75 µM and 2 µM, respectively. SB-431542 also inhibits TGF-beta-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways[1][2][3].
