Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a Ki of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment[1][2][3][4]. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
477.47
Reinheit:
99.23
CAS Nummer:
[146464-95-1]
Formel:
C23H23N7O5
Target-Kategorie:
Antifolate,Apoptosis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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