SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2].
Molekulargewicht:
341.49
CAS Nummer:
[144505-58-8]
Formel:
C16H23NO3S2
Target-Kategorie:
Neprilysin
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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