Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone exhibits potent anti-eosinophilic activity by inducing apoptosis. Orazipone inhibits activation of inflammatory transcription factors NF-kB and STAT 1 and decreases inducible iNOS expression and NO production in response to inflammatory stimuli. Orazipone reduces NADPH oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury[1][2][3].
Molekulargewicht:
266.31
CAS Nummer:
[137109-78-5]
Formel:
C13H14O4S
Target-Kategorie:
Apoptosis,NADPH Oxidase,NF-kappaB,NO Synthase,Reactive Oxygen Species (ROS),STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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