Ancriviroc (SCH-351125) is an orally active CCR5 antagonist. Ancriviroc has a broad-spectrum antiviral activity against HIV-1 isolates using CCR5 as their entry coreceptor (such as ASM 80, 92US715 and YU-2) with IC50s of 0.4-9 nM. Ancriviroc strongly inhibits the replication of R5-using HIV-1 isolates in SCID-hu Thy/Liv mice model of HIV-1 infection. Ancriviroc can be used for HIV infection research[1].
Molekulargewicht:
557.52
CAS Nummer:
[370893-06-4]
Formel:
C28H37BrN4O3
Target-Kategorie:
CCR,HIV
Anwendungsbeschreibung:
MCE Product type: Reference compound
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