TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 µM, 0.3 µM, 0.4 µM, 1.1 µM and 2.2 µM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain[1][2][3].
Molekulargewicht:
516.52
Reinheit:
99.67
CAS Nummer:
[1211866-85-1]
Formel:
C25H27F3N6O3
Target-Kategorie:
Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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