Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4].
Molekulargewicht:
325.36
Reinheit:
99.90
CAS Nummer:
[302841-89-0]
Formel:
C19H19NO4
Target-Kategorie:
mGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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