DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 µM, 6 µM and 6 µM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 µM and 5.7 µM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 µM and 3.2 µM, respectively[1][2][3].
Molekulargewicht:
239.23
Reinheit:
99.54
CAS Nummer:
[205309-81-5]
Formel:
C11H13NO5
Target-Kategorie:
EAAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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