Tris(2-chloroethyl) phosphate (TCEP) is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca) influx, a decrease in mitochondrial membrane potential (psim), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-kappaB pathway, triggering liver inflammation[1][2][3].
Molekulargewicht:
285.49
Reinheit:
97.07
CAS Nummer:
[115-96-8]
Formel:
C6H12Cl3O4P
Target-Kategorie:
Apoptosis,Calcium Channel,DNA/RNA Synthesis,FXR,Interleukin Related,NF-kappaB,Reactive Oxygen Species (ROS),SOD,TNF Receptor,Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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