AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folate receptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 µM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED[1][2].
Molekulargewicht:
467.52
CAS Nummer:
[177575-17-6]
Formel:
C18H21N5O6S2
Target-Kategorie:
Antifolate
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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