BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 µM and 8.0 µM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 µM) than vascular tissue (EC50 of 21.0 µM)[1][2].
Molekulargewicht:
291.35
Reinheit:
99.81
CAS Nummer:
[18200-13-0]
Formel:
C17H17N5
Target-Kategorie:
Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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