Natalizumab (AN100226, BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets alpha4 integrin (CD49d), blocking the interaction of integrins such as alpha4beta1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the alpha4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4+ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohns disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses[1][2][3][4][5].
Molekulargewicht:
(146.22 kDa)
Reinheit:
99
CAS Nummer:
[189261-10-7]
Target-Kategorie:
Integrin
Anwendungsbeschreibung:
MCE Product type: Inhibitory Antibodies
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