SB-334867 free base (SB334867A free base) is an excellent, selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively[1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo[2][3].
Molekulargewicht:
319.32
Reinheit:
99.88
CAS Nummer:
[792173-99-0]
Formel:
C17H13N5O2
Target-Kategorie:
Orexin Receptor (OX Receptor)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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