Edicotinib hydrochloride is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib hydrochloride exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib hydrochloride limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib hydrochloride has the potential for Alzheimers disease and rheumatoid arthritis research[1][2].
Molekulargewicht:
498.06
CAS Nummer:
[1559069-92-9]
Formel:
C27H36ClN5O2
Target-Kategorie:
c-Fms
Anwendungsbeschreibung:
MCE Product type: Reference compound
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