AM6545 is a highly selective, brain-free (peripherally active) CB1 receptor antagonist (Ki=1.7 nM). AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment (such as proteinuria, fibrosis) and insulin resistance. AM6545 can be used in the study of obesity and its complications[1][2][3].
Molekulargewicht:
556.46
Reinheit:
99.32
CAS Nummer:
[1245626-05-4]
Formel:
C26H23Cl2N5O3S
Target-Kategorie:
Cannabinoid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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