MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC50 = 13 nM) and functional agonist activity (EC50 = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC50) on mouse MC4R and 1.7 µM (EC50) on mouse MC3R. MK-0489 can be used for the study of obesity[1].
Molekulargewicht:
600.18
CAS Nummer:
[778625-65-3]
Formel:
C34H44ClF2N3O2
Target-Kategorie:
Melanocortin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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