Romaciclib (monohydrochloride), CAS [[2443816-41-7]]

Produktübersicht

• Artikelname: Romaciclib (monohydrochloride), CAS [[2443816-41-7]]
• Artikelnummer: MCE-HY-111388A
• Hersteller Artikelnummer: HY-111388A
• Alternativnummer: MCE-HY-111388A-10MMX1ML,MCE-HY-111388A-10MG,MCE-HY-111388A-100MG,MCE-HY-111388A-50MG,MCE-HY-111388A-25MG,MCE-HY-111388A-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: SEL120-34A (monohydrochloride)

Produktbeschreibung

SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726[1]. Has anti-tumor activity[1].

Produkteigenschaften

• Molekulargewicht: 450.60
• Reinheit: 99.29
• CAS Nummer: [2443816-41-7]
• Formel: C15H19Br2ClN4
• Target-Kategorie: CDK

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound