Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression[1].
Molekulargewicht:
534.60
Reinheit:
99.95
CAS Nummer:
[2222941-37-7]
Formel:
C30H32F2N4O3
Target-Kategorie:
Epigenetic Reader Domain
Anwendungsbeschreibung:
MCE Product type: Reference compound
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