1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated beta-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 µM and 4.31 µM, respectively, and binds to UGT1A1 with Ki of 3.55 µM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease[1][2][3].
Molekulargewicht:
788.57
Reinheit:
99.08
CAS Nummer:
[79886-50-3]
Formel:
C34H28O22
Target-Kategorie:
UGT
Anwendungsbeschreibung:
MCE Product type: Natural Products
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