TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 (IC50=18 nM), PHD2 (Ki=5.3 nM), and PHD3 (IC50=63 nM), and targets monkey PHD2 with an IC50 of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFalpha, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia[1][2].
Molekulargewicht:
431.83
Reinheit:
99.25
CAS Nummer:
[1558021-37-6]
Formel:
C20H18ClN3O6
Target-Kategorie:
HIF/HIF Prolyl-Hydroxylase
Anwendungsbeschreibung:
Reference compound
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