(1R)-IDH889, CAS [[1429179-08-7]]

Produktübersicht

• Artikelname: (1R)-IDH889, CAS [[1429179-08-7]]
• Artikelnummer: MCE-HY-112289B
• Hersteller Artikelnummer: HY-112289B
• Alternativnummer: MCE-HY-112289B-25MG,MCE-HY-112289B-50MG,MCE-HY-112289B-10MMX1ML,MCE-HY-112289B-100MG,MCE-HY-112289B-10MG,MCE-HY-112289B-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(1R)-IDH889 is the isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 µM, 0.072 µM and 1.38 µM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 µM[1].

Produkteigenschaften

• Molekulargewicht: 436.48
• Reinheit: 98.83
• CAS Nummer: [1429179-08-7]
• Formel: C23H25FN6O2
• Target-Kategorie: Isocitrate Dehydrogenase (IDH)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound