MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 µM), MK-5 (IC50=0.081 µM), ERK2 (IC50=3.44 µM), MNK1(IC50=5.7 µM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1].
Molekulargewicht:
358.39
Reinheit:
99
CAS Nummer:
[1186648-22-5]
Formel:
C21H18N4O2
Target-Kategorie:
MAPKAPK2 (MK2)
Anwendungsbeschreibung:
Reference compound
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