NF449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 is a Gsalpha-selective G Protein antagonist. NF449 suppresses the rate of GTP[gammaS] binding to Gsalpha-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of beta-adrenergic receptors to Gs[1][2].
Molekulargewicht:
1329.24
CAS Nummer:
[389142-38-5]
Formel:
C41H32N6O29S8
Target-Kategorie:
P2X Receptor
Anwendungsbeschreibung:
Reference compound
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