Cdk1/2 Inhibitor III (compound 3n) is a highly potent and selective Cdk1/cyclin B and Cdk2/cyclin A inhibitor of with IC50s of 0.6 nM and 0.5 nM, respectively. Cdk1/2 Inhibitor III shows selectivity over VEGF-R2 (IC50 of 32 nM), GSK-3beta (IC50 of 140 nM), and a other kinases. Cdk1/2 Inhibitor III inhibits in cell proliferation with IC50s of 20 nM, 35 nM and 92 nM for HCT-116, HeLa, and A375 cells, respectively[1].
Molekulargewicht:
425.44
Reinheit:
99.69
CAS Nummer:
[443798-55-8]
Formel:
C15H13F2N7O2S2
Target-Kategorie:
CDK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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