IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
Molekulargewicht:
492.61
Reinheit:
99.29
CAS Nummer:
[500715-03-7]
Formel:
C31H32N4O2
Target-Kategorie:
Potassium Channel
Anwendungsbeschreibung:
Reference compound
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