Guanosine triphosphate-13C10,15N5 (tetraammonium) solution (100 mM) Preis auf Anfrage
Artikelnummer:
MCE-HY-113225S1
Hersteller Artikelnummer:
HY-113225S1
Alternativnummer:
MCE-HY-113225S1-1MG
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
GTP-13C10,15N5 (tetraammonium)
Guanosine triphosphate-13C10,15N5 tetraammonium is the 13C and 15N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate tetraammonium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tetraammonium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tetraammonium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic beta-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tetraammonium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tetraammonium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism[1][2][3].
