RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2].
Reinheit:
98
CAS Nummer:
[1219927-22-6]
Formel:
C21H19F2N5OS.xHCl
Target-Kategorie:
CRAC Channel,Interleukin Related
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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