WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice[1][2].
Molekulargewicht:
410.44
Reinheit:
99.76
CAS Nummer:
[1913291-02-7]
Formel:
C21H18N2O5S
Target-Kategorie:
Discoidin Domain Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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