BI-9321, a chemical probe, is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 µM in U2OS cells[1].
Molekulargewicht:
360.43
CAS Nummer:
[2387510-86-1]
Formel:
C22H21FN4
Target-Kategorie:
Histone Methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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