Basimglurant (sulfate), CAS [[1034442-21-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Basimglurant (sulfate), CAS [[1034442-21-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-114515
• Hersteller Artikelnummer: HY-114515
• Alternativnummer: MCE-HY-114515-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: RG7090 (sulfate), RO4917523 (sulfate)

Produktbeschreibung

Basimglurant (RG7090, RO4917523) sulfate is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [3H]-ABP688 (HY-110141)) and 35.6 nM (against [3H]-MPEP (HY-14609A)). Basimglurant sulfate inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters delta-wave power during non-rapid eye movement sleep. Basimglurant sulfate can be used in research on depression, fragile X syndrome, anxiety disorders, etc[1][2].

Produkteigenschaften

• Molekulargewicht: 423.85
• CAS Nummer: [1034442-21-1]
• Formel: C18H15ClFN3O4S
• Target-Kategorie: mGluR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound