CP-339818 is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC50s of 18.9 µM and 43.4 µM against HCN1 and HCN4 (high Cl-). CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels[1][2][3].
Molekulargewicht:
304.43
CAS Nummer:
[185855-91-8]
Formel:
C21H24N2
Target-Kategorie:
HCN Channel,Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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