SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 µM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma[1].
Molekulargewicht:
397.25
CAS Nummer:
[388086-13-3]
Formel:
C21H14Cl2N2O2
Target-Kategorie:
Sirtuin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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