Phelorphan is a purine MTH1 inhibitor identified through chemical array screening. Although it targets cellular MTH1, its cytotoxicity to cancer cells is weaker than that of other reported inhibitors. The cytotoxicity of MTH1 inhibitors may be attributed to off-target effects, and MTH1 is not essential for cancer cell survival.
Molekulargewicht:
386.46
CAS Nummer:
[110871-16-4]
Formel:
C20H22N2O4S
Target-Kategorie:
Others
Anwendungsbeschreibung:
MCE Product type: Reference compound
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