Simmiparib, CAS [[1551355-46-4]]

Produktübersicht

• Artikelname: Simmiparib, CAS [[1551355-46-4]]
• Artikelnummer: MCE-HY-115552
• Hersteller Artikelnummer: HY-115552
• Alternativnummer: MCE-HY-115552-50MG,MCE-HY-115552-25MG,MCE-HY-115552-100MG,MCE-HY-115552-5MG,MCE-HY-115552-10MG,MCE-HY-115552-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Simmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC50 values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib (HY-10162). Simmiparib induces DNA double-strand breaks (DSB) accumulation and G2/M arrest in homologous recombination repair (HR)-deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts[1].

Produkteigenschaften

• Molekulargewicht: 486.42
• Reinheit: 99.01
• CAS Nummer: [1551355-46-4]
• Formel: C23H18F4N6O2
• Target-Kategorie: PARP

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound