ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 (KCC2) with an IC50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak (IC50 > 50 µM). ML077 inhibits the chloride ion excretion function of KCC2, increasing the intracellular chloride ion concentration, thereby enhancing the depolarization mediated by chloride ion channels. ML007 can promote glucose-stimulated insulin secretion (GSIS) without relying on KATP channels. ML007 can be used to study the functions related to pain, epilepsy, and insulin secretion[1][2].
Molekulargewicht:
356.47
CAS Nummer:
[1135304-61-8]
Formel:
C17H16N4OS2
Target-Kategorie:
Endogenous Metabolite,NKCC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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