Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 µM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
Molekulargewicht:
462.51
Reinheit:
98.02
CAS Nummer:
[108005-94-3]
Formel:
C27H27FN2O4
Target-Kategorie:
Cathepsin
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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